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KMID : 0613820160260030359
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Journal of Life Science
2016 Volume.26 No. 3 p.359 ~ p.363
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Screening of Natural Product Libraries for the Extension of Cell Life-span through Immune System
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Yoo Bo-Kyung
Kwon Ki-Sang
Ko Young-Hwa
Kim Hong-Geun
Lee Seok-Hyun
Park Kwan-Ho
Choi Ji-Young
Kwon O-Yu
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Abstract
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We have screened four natural products against 640 single compounds, which shows more two folds gene expression for both endoplasmic reticulum aminopeptidase 1 (ERAP1) and FOXO-family transcription factor (FOXO1). The results were as follows. (±)-Car-3-ene-2,5-dione from Asarum sieboldii Miq. is C10H12O2 molecular formula and the 164 kDa molecular weight. Cinobufagin from Bufonis Venennum is C26H34O6 molecular formula and 442 kDa molecular weight. So far reported main biological function is Na+/K+-ATPase inhibition. Corilagin from Euphorbia pekinensis is C27H22O18 molecular formula and 634 kDa molecular weight. Carbonic anhydrase inhibition is well known its biological function. Corydaline from Corydalis turtschaninovii is C22H27NO4 molecular formula and 369 kDa molecular weight. The main biological function is acetylcholinesterase inhibition. In the short future, four types of natural products will be used in longevity experiments with insects. The results may give one of the clues for studying new drug development candidates of the longevity.
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KEYWORD
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Cell life-span extension, (±)-Car-3-ene-2, 5-dione, Cinobufagin, Corilagin, Corydaline
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